Laboratory of Nanoscale Biology: Cellular Structural Biology and Multi-Scale Bioimaging
Cellular Structural Biology
Using core stengths in electron tomography and protein bioengineering the cellular structural biology group focuses on analysis of 3D structures of biological macromolecules in the cell, in particular using cryo-electron tomography.
Biomolecular Nanoengineering
Our research focuses on structure-based protein engineering to create biomolecules with novel functionalities.
Structural Neurobiology
We investigate the structure and function of healthy and diseased brains using a dynamical connectomics approach combining in vivo multiphoton calcium imaging in behaving mice with multi-scale electron and X-ray microscopy for dense, synaptic resolution neuronal circuit reconstruction.
Structural Biology of Neuronal Systems
In the context of research on neurodegenerative diseases, we investigate the structure and function of neurodegenerative amyloid proteins by integrative biophysical methods.