About the Lab of Nanoscale Biology
The Laboratory of Nanoscale Biology (LNB) investigates the molecular structure and dynamics of complex molecular machines and cascades in the context of the living cell. Current strengths of LNB include technology innovation and the uncovering of structure-function relationships in specific biological contexts. Using our distinct expertise, we engage in the development and improvement of novel methods for electron microscopy and diffraction. In addition, we have unique capabilities in protein bioengineering, (bio-)microfabrication and correlative imaging methods. LNB’s scientific strengths are to link structural information to functional contexts at length scales ranging from proteins to single cells to tissue. Typical examples include it situ studies on eukaryotic cilia proteins in their natural context, studies of protein aggregation or chromatin structure in the context of cell function as well as computation of connectome maps of the brain based on bio-imaging data to reveal new insights into brain function.