On the 7th to 12th of August 2018, a collaborative group of scientists from the Paul Scherrer Institute and members of the LeadXpro and Heptares pharmaceutical companies led by Karol Nass (PSI macromolecular crystallography MX-SLS group) performed the first serial femtosecond crystallography (SFX) pilot user experiment at the Swiss X-ray free electron laser SwissFEL. Serial femtosecond crystallography is an emerging technique for structure determination of radiation sensitive micro-crystals that takes advantage of the ultra-short pulse durations from an XFEL and allows access to reaction time scales previously not reachable by conventional time-resolved crystallography read more.
Since it was first established in 1987, the annual Regio-Meeting has been instrumental in facilitating interactions in the structural biology community in southwestern Germany, the eastern region of France and an expanding area of Switzerland. It is set as an informal event to foster young scientists to discuss their research results in an international context.
The 2018 edition will take place in the heart of Switzerland in Emmetten from September 26 to 28, 2018.
Registration and abstract submission deadline: September 7, 2018.
In the week of March 18-23 PSI welcomes 20 PhD students and postdocs taking part in
the HERCULES 2018 school on Neutron and Synchrotron Radiation. They will attend
lectures and perform two days of practical courses at several beam lines of the Swiss
Fluid catalytic cracking catalysts are composite particles of hierarchical porosity were examined using ptychographic X-ray tomography. These particles are essential to the conversion of crude oil into gasoline. Examination of catalysts at decreasing levels of catalytic conversion efficacy allowed the detection of possible deactivation causes.
A workshop dedicated to the presentation of the in meso in situ serial crystallography (IMISX) method (Huang et al. 2015, 2016 ActaD) for the X-ray structure determination of membrane proteins is organised at the Swiss Light Source at PSI for the second time. It will be held between November 27 and 29, 2017.
The workshop consists of introductory lectures, as well as presentations of serial crystallography activities at various synchrotron facilities. The main part of the workshop focus on hands-on practicals on methods for growing crystals of membrane proteins by the in meso or LCP method, for collecting serial diffraction data on micro-crystals directly in situ and for processing the data most efficiently for high-resolution structure determination.
For the first time, scientists have made visible the directions of the magnetisation inside a 3D magnetic object. The smallest details in their visualisation were ten thousand times smaller than a millimetre. Among others, the magnetic structure contained one outstanding kind of pattern: magnetic singularities called Bloch points, which up to now were only known in theory.
A very thin layer on this beetle’s wings exhibits a complicated structure on the nanoscale that gives them a bright white color. X-ray nanotomography acquired at the Swiss Light Source provides a faithful image of this structure in three dimensions with which scientists can confirm its evolutionary optimization: just enough material for an efficient reflection of white light.
Researchers from China and USA join forces with Swiss Light Source (SLS) macromolecular crystallography (MX) beamline scientists in a study, which aims at understanding an important step in the life cycle of the human betacoronavirus HKU1.
Researchers at the PSI have made detailed 3-D X-ray images of a commercially available computer chip. In their experiment, they examined a small piece that they had cut out of the chip beforehand. This sample remained undamaged throughout the measurement. It is a major challenge for manufacturers to determine if, in the end, the structure of their chips conforms to the specifications. Thus these results represent one important application of an X-ray tomography method that the PSI researchers have been developing for several years.