Dr. Sylvain Antoine Engilberge


Postdoctoral researcher 

Paul Scherrer Institute
Forschungsstrasse 111
5232 Villigen PSI


Sylvain received a Ph.D. in physics for life sciences from Grenoble Alpes University in 2017. After a first postdoctoral position at National University of Ireland - Galway, Sylvain joined the MX group in 2019. 

Research interests

Sylvain's research activities include protein crystallisation, data collection, de novo phasing and structures refinement.


17. Monitoring the production of diffraction-quality enzyme crystals in real time using in situ dynamic light scattering. R. De Wijn, K. Rollet, S. Engilberge, A. McEwen, O. Hennig, H. Betat, M. Mörl, F. Riobe, O. Maury, E. Girard,   P. Bénas, B. Lorber, C. Sauter. Crystals, 2020, 10(2):65.

16. Engineered assembly of a protein-cucurbituril biohybrid.F. Guagnini, S. Engilberge, K. Ramberg, J. Pérez, P. B. Crowley. Chem Commun, 2020, 56, 360-363.

15. Crystal structure of a protein-aromatic foldamer composite: macromolecular chiral resolution.J. M. Alex, V Corvaglia, X Hu,S.Engilberge, I. Huc, P. B. Crowley. Chem Commun, 2019, 74, 11087-11090.

14. Tuning Protein Frameworks via Auxiliary Supramolecular Interactions.S. Engilberge*, M.L Rennie, E. Dumont, P.B Crowley. ACS Nano. 2019, 9, 10343-10350.

13. Calixarene-Capture of Partially Unfolded Cytochrome c.S. Engilberge*, M.L Rennie, P.B Crowley. FEBS Lett. 2019, 16, 2112-2117.

12. Protein crystal structure determination with the crystallophore, a nucleating and phasing agent.S. Engilberge*, T. Wagner*, G. Santoni, C. Breyton, S. Shima, B. Franzetti, F. Riobé, O. Maury, E. Girard. J Appl Crystallogr. 2019, 52,722-731.

11. Medical contrast media as highly efficient tools for SAXS contrast variation. F. Gabel, S. Engilberge, J. Pérez, E. Girard. IUCrJ. 2019, 6, 521-525.

10. A versatile microfluidic device for simple and efficient biomolecule crystallization and structural analysis by serial crystallography.R. De Wijn, O. Hennig, J. Roche, S. Engilberge, K. Rollet, P. Fernandez-Millan, K. Brillet, H. Betat, M. Mörl, A. Roussel, E. Girard, C. Mueller-Dieckmann, G. C. Fox, V. Oliéric, J. A. Gavira, B. Lorber, C. Sauter.              IUCRJ 2019, 6, 454-464.

9. Recognition and Assembly of a small anti-fungal protein by Sulfonato-calix[n]arenes. J. M. Alex, M. L. Rennie, S. Engilberge, H. Dorothea, F. Adam, G. Batta, P. B. Crowley. IUCRJ,2019, 6, 238-247.

8. The multi-catalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite. I. Bernhardsgrütter, B. Vögeli, T. Wagner, D. Peter, N. Socorro Cortina, G. Bange,S. Engilberge, E. Girard, F. Riobé, O. Maury, S. Shima, J. Zarzycki, T. Erb. Nat. Chem. Biol.2018, 14, 1127-1132.

7. Unveiling the binding modes of the crystallophore, a terbium-based nucleating and phasing molecular agent for protein crystallography. S. Engilberge*, F. Riobé, T. Wagner, S. Di Pietro, C. Breyton, B. Franzetti, S. Shima, E. Girard, E. Dumont, O. Maury. Chem. Eur. J.2018, 24, 9739-9746

6. The archaeal acetoacetyl-CoA-thiolase/HMG-CoA-synthase complex channels the intermediate via a fused CoA-binding site. B. Voegeli, S. Engilberge, E. Girard, F. Riobé, O. Maury, T. J. Erb, S. Shima, T. Wagner. Proc. Natl. Acad. Sci. USA2018,13, 3380-3385.

5. Crystallophore: a versatile lanthanide complex for protein crystallography combining nucleating effect, phasing properties and luminescence. S. Engilberge*, F. Riobé*, S. Di Pietro, L. Lassalle, N. Coquelle, C.-A. Arnaud,  D. Pitrat, J.-C. Mulatier, D. Madern, C. Breyton, O. Maury, E. Girard. Chem. Sci. 2017,8, 5909-5917.

4. Structural Insight intoUbiquitin-Like Protein Recognition and Oligomeric States of JAMM/MPN+ Proteases.S. Cao*, S. Engilberge*, E. Girard, F. Gabel, B. Franzetti, J. Maupin-Furlow. Structure 2017,25, 823-833.

3. Bacteriophage T5 tail tube structure suggests a trigger mechanism for Siphoviridae DNA ejection. C. A. Arnaud, G. Effantin, C. Vivès, S. Engilberge, M. Bacia, P. Boulanger, E. Girard, G. Schoehn, C. Breyton. Nat. Commun. 2017,8, 1953

2. New insights into the mechanism of substrates traficking in Glyoxylate/ Hydroxypyruvate reductases. L. Lassalle, S. Engilberge, D. Madern, P. Vauclare, B. Franzetti E. Girard. Sci. Rep.2016,6, 20629

1. Structural Basis for Enantioselectivity in the Transfer Hydrogenation of a Ketone Catalyzed by an Artificial Metalloenzyme. M. V. Cherrier, S. Engilberge, P. Amara, A. Chevalley, M. Salmain, J. C. Fontecilla-Camps. Eur. J. Inorg. Chem. 2013, 21, 3596–3600.