News

Scientists at the Paul Scherrer Institute and ETH Zurich have created 3D images of tiny objects showing details down to 25 nanometres. In addition to the shape, the scientists determined how particular chemical elements were distributed in their sample and whether these elements were in a chemical compound or in their pure state.

Researchers at the Paul Scherrer Institute (PSI) have succeeded in switching tiny, magnetic structures using laser light and tracking the change over time. In the process, a nanometre-sized area bizarrely reminiscent of the Batman logo appeared. The research results could render data storage on hard drives faster, more compact and more efficient.

All living organisms, from bacteria to humans, rely on proteins to perform their vital functions. How these proteins accomplish their tasks depends on their structure. Researchers from the Paul Scherrer Institute have now devised a novel method to determine the crystal structure of proteins using X-ray light, which could also hasten the development of new drugs in future. The study will be published in the journal Nature Methods on 15 December.

New effect might be important for emergence of High-Temperature SuperconductivityAn international team of researchers has observed a new, unexpected kind of behaviour in copper-based high-temperature superconductors. Explaining the new phenomenon à an unexpected form of collective movement of the electrical charges in the material à poses a major challenge for the researchers. A success in explaining the phenomenon might be an important step toward understanding high-temperature superconductivity in general. The crucial experiments were conducted at the Paul Scherrer Institute.

The need for ever faster and more efficient electronic devices is growing rapidly, and thus the demand for new materials with new properties. Oxides, especially ones based on strontium titanate (SrTiO₃), play an important role here. A collaborative project headed by scientists from the PSI has now revealed properties of strontium titanate that make it an important base material for applications in spintronics.

PSI researchers garner experience for SwissFEL experimentsAided by short laser flashes, researchers at the Paul Scherrer Institute have managed to temporarily change a material’s properties to such a degree that they have à to a certain extent àcreated a new material. This was done using the x-ray laser LCLS in California. Once the PSI x-ray laser SwissFEL is up and running, experiments of this kind will also be possible at PSI.

New analyses of tiny fossil mammals from South Wales are shedding light on the function and diets of our earliest ancestors, a team led by researchers from the Universities of Bristol and Leicester report in the journal Nature. The team used CT scanning with synchrotron X-rays at PSI’s Swiss Light Source to reveal in unprecedented detail the internal anatomy of the mammals’ tiny jaws.

Researchers at the PSI, the EPFL and the Chinese Academy of Science, have proven that the material SmB₆ shows all the properties of a so called topological insulator à a material with electric currents flowing along its surface with all of them being polarized. Here, the property is very robust, i.e. the only current that can flow is spin polarized and is not easily destroyed by small irregularities in the structure or composition of the material. Spin polarized currents are necessary for spintronics, electronics using the electrons’ spin.

Researchers from the Paul Scherrer Institut (PSI) have devised a method that opens up new scales of tomographic imaging and will thus allow in the future highly resolved measurements of biological and materials science specimens. With the aid of a special prototype instrument at the Swiss Light Source (SLS), they achieved a 3D resolution of sixteen nanometres in a large sample and thus set a new world record in X-ray tomography.

Scientists have used a particle accelerator to obtain high-speed 3D X-ray visualizations of the flight muscles of flies. The team from Oxford University, Imperial College, and the Paul Scherrer Institute (PSI) developed a groundbreaking new CT scanning technique at the PSI’s Swiss Light Source to allow them to film inside live flying insects. The movies offer a glimpse into the inner workings of one of nature’s most complex mechanisms, showing that structural deformations are the key to understanding how a fly controls its wingbeat.

Botox is a highly dangerous toxin that causes paralysis. In cosmetic applications it is used to temporarily eliminate wrinkles and in medicine as a treatment for migraine or to correct strabismus. An international research team has now established how the toxin molecule binds to the neuron whose activity is then blocked by the poison. The findings may be useful for the development of improved drugs with a lower risk of overdosage.

Above the transition temperature, some electrons in the superconducting material La_1.77Sr_0.23CuO₄ behave as if they were in a conventional metal, others as in an unconventional one à depending on the direction of their motion. This is the result of experiments performed at the SLS. The discovery of this anisotropy makes an important contribution towards understanding high-temperature superconductors. The effect will also have to be taken into account in future experiments and theories of high-temperature superconductors.

Helena Van Swygenhoven, materials researcher at the Paul Scherrer Institute and professor at the Swiss Federal Institute of Technology in Lausanne (EPFL), has been awarded an ERC Advanced Grant. This prestigious EUR 2.5 million grant from the European Research Council will enable Van Swygenhoven to launch the new research project MULTIAX. Under this project, she will investigate what happens in metallic materials during deformation - a question important for the production processes for car parts. Furthermore, the project will also develop new methods that can be used to study materials at large research facilities. These methods will be accessible to experts from research and industry.

Mit Hilfe von Röntgenlicht aus der Synchrotron Lichtquelle Schweiz des PSI ist es Paläontologen der Universität Bristol gelungen, ein Rätsel um den Ursprung der ersten Wirbeltiere mit harten Körperteilen zu lösen. Sie haben gezeigt, dass die „Zähne“ altertümlicher Fische (der sogenannten Conodonten) unabhängig von den Zähnen und Kiefern heutiger Wirbeltiere entstanden sind. Die Zähne dieser Wirbeltiere haben sich vielmehr aus einem Panzer entwickelt, der dem Schutz vor den Conodonten, den ersten „Raubtieren“, diente.

Scientists use nano-rods to investigate how matter assemblesTo make the magnetic interactions between the atoms visible, scientists at the Paul Scherrer Institute PSI have developed a special model system. It is so big that it can be easily observed under an X-ray microscope, and mimics the tiniest movements in Nature. The model: rings made from six nanoscale magnetic rods, whose north and south poles attract each other. At room temperature, the magnetisation direction of each of these tiny rods varies spontaneously. Scientists were able to observe the magnetic interactions between these active rods in real time. These research results were published on May 5 in the journal “Nature Physics”.

Scientists at the Paul Scherrer Institute, together with Chinese and German collaborators, have obtained new insights into a class of high-temperature superconductors. The experimental results of this fundamental research study indicate that magnetic interactions are of central importance in the phenomenon of high-temperature superconductivity. This knowledge could help to develop superconductors with enhanced technical properties in the future.

X-rays are used to investigate nanoscale structures of objects as varied as single cells or magnetic storage media. Yet, high-resolution images impose extreme constraints on both the X ray microscope and the samples under investigation. Researchers at the Technische Universität München the PSI now showed how to relax these conditions without loss of image quality. They further showed how to image objects featuring fast fluctuations, such as the rapid switching events that determine the life time of data storage in magnetic materials.

Researchers from the Paul Scherrer Institute and the Indian Institute of Science Education and Research have been able to intentionally ‘switch off’ the magnetization of every second molecule in an array of magnetized molecules and thereby create a ‘magnetic nano-chessboard’. To achieve this, they manipulated the quantum state of a part of the molecules in a specific way.

Anti-cancer drugs are used under the heading of “Chemotherapeutics” to prevent cells from dividing. Because the cells in a growing tumour divide more frequently than others, tumour cells are damaged more severely. Scientists at the Paul Scherrer Institute and the ETH Zurich have now clarified the exact mechanism of action of one class of these drugs. The data acquired is so accurate, that targeted drugs could now be developed that are even better suited to fulfil their task.

Until recently, it was not obvious whether the earliest vertebrates (animals with a backbone) which had jawbones already possessed teeth or not. Now, an international research team has shown that the jaws of the prehistoric fish Compagopiscis already had teeth. This means that teeth appeared at the same evolutionary time as jaws à or at least shortly afterwards. The leaders of this project were scientists from the University of Bristol, England, who carried out their decisive experiments at the SLS at PSI.

Experiments performed at the Paul Scherrer Institute (PSI) investigate processes inside volcanic materials that determine whether a volcano will erupt violently or mildly. In the experiments, scientists heated small pieces of volcanic material similarly to conditions present at the beginning of a volcanic eruption. They used X-rays from the SLS to observe, in real time, what happens to the rock as it goes from the solid to the molten state.

A new X-ray technique provides insights into the magnetic properties of atomically thin layers of a parent compound of a high-temperature superconductor. It turns out that the magnetic properties of material films which are only a few atoms thick differ by only a surprisingly small degree from those of macroscopically thick samples. In the future, this method can be used to study the processes occurring in very thin layers of superconductors and help us to understand this intriguing phenomenon.

Researchers have succeeded in generating detailed three-dimensional images of the spatial distribution of amyloid plaques in the brains of mice afflicted with Alzheimer’s disease. The new technique used in the investigations provides an extremely precise research tool for a better understanding of the disease. In the future, scientists hope that it will also provide the basis for a new and reliable diagnosis method. The results were achieved within a joint project of two research teams à one from the Paul Scherrer Institute (PSI) and ETH Zurich, the other from the École Polytechnique Fédérale de Lausanne (EPFL).

An electron has been observed to decay into two separate parts, each carrying a particular property of the electron: a spinon carrying its spin à the property making the electron behave as a tiny compass needle à and an orbiton carrying its orbital moment à which arises from the electron’s motion around the nucleus. These newly created particles, however, cannot leave the material in which they have been produced.

Researchers at the Paul Scherrer Institute are finding out how long it takes to establish magnetism and how this happens. Establishing a magnetically ordered phase in the metallic alloy iron-rhodium takes much longer than the reverse process of demagnetization. The result comes from basic research, but has relevance for the computer industry, as it shows which processes limit the speed of magnetic data storage and where improvements might be made.

Like a shredder, the immunoproteasome cuts down proteins into peptides that are subsequently presented on the cellular surface. The immune system can distinguish between self and non-self peptides and selectively kills cells that present non-self peptides at their surface. In autoimmune diseases, this mechanism is deregulated. However, inhibition of the immunoproteasome may alleviate disease symptoms and progression. With the help of measurements taken at the Paul Scherer Institute, scientists have now succeeded in determining the first structure of an immunoproteasome.

An international research team has demonstrated a new way to record information on a magnetic medium without the use of a magnetic field. Instead, they found that they could record information using only a heat pulse. This method of recording might allow one to record Terabytes (1000s of Gigabytes) of information per second being 100s of times faster than present hard drive technology, and consumes much less energy by using heat without the need for a magnetic field. Using modern lithographic methods and x-ray microscopy, researchers from the Paul Scherrer Institute contributed considerably to this work.

Einzellige Organismen, die vor über einer halben Milliarde Jahre gelebt haben und deren Fossilien in China gefunden wurden, sind wohl die unmittelbaren Vorläufer der frühesten Tiere. Die amöbenartigen Einzeller haben sich in einer Weise in zwei, vier, acht usw. Zellen geteilt, wie es heute tierische (und menschliche) Embryonen tun. Die Forscher glauben, dass diese Organismen einem der ersten Schritte vom Einzeller zum Vielzeller in der Entwicklung richtiger Tiere entsprechen.This news release is only available in German.

Lebende Zellen empfangen dauernd Informationen von aussen, die über Rezeptoren in das Zellinnere weitergeleitet werden. Genetisch bedingte Fehler in solchen Rezeptoren sind der Grund für zahlreiche Erbkrankheiten darunter verschiedene hormonelle Funktionsstörungen oder Nachtblindheit. Forschern des Paul Scherrer Instituts ist es nun erstmals gelungen, die exakte Struktur eines solchen fehlerhaften Rezeptors aufzuklären.This news release is only available in German.

Forscher der Universität Basel und des Paul Scherrer Instituts konnten im Nanomassstab zeigen, wie sich Karies auf die menschlichen Zähne auswirkt. Ihre Studie eröffnet neue Perspektiven für die Behandlung von Zahnschäden, bei denen heute nur der Griff zum Bohrer bleibt. Die Forschungsergebnisse wurden in der Fachzeitschrift «Nanomedicine» veröffentlicht.This news release is only available in German.

Mit einem Festakt hat das Paul Scherrer Institut (PSI) in Villigen (AG) heute an das zehnjährige Bestehen ihrer bedeutendsten Grossforschungsanlage erinnert. Seit der Inbetriebnahme im Sommer 2001 haben Tausende von Forschern aus Hochschule und Industrie an der Synchroton Lichtquelle Schweiz (SLS) qualitativ hochwertige Experimente durchgeführt. Ihre Forschung mündete in über 2000 wissenschaftlichen Publikationen und brachte darüber hinaus einen Nobelpreis sowie eine Vielzahl industrieller Anwendungen hervor.This news release is only available in German.

Reorganisation of the brain and sense organs could be the key to the evolutionary success of vertebrates, one of the great puzzles in evolutionary biology, according to a paper by an international team of researchers, published today in Nature. The study claims to have solved this scientific riddle by studying the brain of a 400 million year old fossilized jawless fish à an evolutionary intermediate between the living jawless and jawed vertebrates.

An international team of researchers has developed a new method for making detailed X-ray images of brain tissue, which has been used to make the myelin sheaths of nerve fibres visible. Damage to these protective sheaths can lead to various disorders, such as multiple sclerosis. The facility for creating these images of the protective sheaths of nerve cells is being operated at the Swiss Light Source (SLS), at the Paul Scherrer Institute.

At the beginning of the process of sight, light interacts with a protein molecule called Rhodopsin. This molecule contains the actual light sensor that is stimulated by the incoming light and changes its form, in order to trigger the rest of the process. Researchers have now managed to determine the exact structure of the Rhodopsin molecule in its short-lived, excited state. From this, they have obtained a precise picture of the first step of the process of sight.

In menschlichen Zellen finden sich stammesgeschichtlich sehr alte Funktionseinheiten, die als Centriolen bezeichnet werden. Ein Forscherteam vom PSI und der ETH Lausanne hat nun erstmals ein Modell für die Bildung der Centriolen vorgestellt. Das erstaunende Ergebnis ist, dass die Neuner-Symmetrie des Centriols durch die Fähigkeit eines einzelnen Proteins sich selbst zu organisieren zustande kommt.This news release is only available in French and German.

Ribosomes are the protein factories of the living cell and themselves very complex biomolecules. Now, a French research group has for the first time determined the structure of the ribosome in a eukaryotic cell à a complex cell containing a cell nucleus. An important part of the experiments was performed with synchrotron light at the Swiss Light Source SLS of the Paul Scherrer Institute.

For decades researchers have searched for magnetic monopoles à isolated magnetic charges that can move freely like electric charges. Now a team of researchers from the Paul Scherrer Institute and University College Dublin have been able to produce monopoles in the form of quasiparticles in an assembly of nanoscale magnets and have directly observed how they move.

High-resolution method for computed nano-tomography developedA novel nano-tomography method developed by a team of researchers from the Technische Universität München, the Paul Scherrer Institute and the ETH Zurich opens the door to computed tomography examinations of minute structures at nanometer resolutions. The new method makes possible, for example, three-dimensional internal imaging of fragile bone structures.

Many important materials are composed of several phases. When such a material is heated, atoms move from one phase to another, which changes the distribution of the phases à and thus, the properties of the material. A team of researchers has now shown that for an important case, there is a general law describing this process that is valid for all classes of materials.