We report muon-spin rotation measurements of the pressure dependence of the oxygen-isotope (16O / 18O) effect on the spin-density wave (SDW) transition in the trilayer Ruddlesden-Popper nickelate Pr4Ni3O10. At ambient pressure, the SDW transition shows a finite isotope shift, with 16TSDW = 158.04(5) K and 18TSDW = 159.81(6) K. Under hydrostatic pressure, TSDW decreases linearly at rates that are equal within uncertainty for the two isotope compositions, d16TSDW /dp= −4.93(5) K/GPa and d18TSDW /dp= −4.90(7) K/GPa, such that the isotope shift remains constant within uncertainty under compression. The absence of pressure enhancement of the isotope effect points to a predominantly electronic origin of the SDW transition and is consistent with recent inelastic x-ray scattering results, suggesting a regime of intertwined order in trilayer RP nickelates, which is stabilized by strong spin interactions.