Lab News & Scientific Highlights

Datum
Ligand induced dimerization of GPCR

Biased signalling for better drugs

A dream drug would provide a targeted therapeutic effect without side effects. Biased signalling could make this a reality. Publishing in PNAS, PSI researchers present a platform for biased signalling-based drug discovery.

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amb_cu_teaser

Fingerprint of Copper in Peptides Linked to Alzheimer's Disease

In an interdisciplinary project, researchers from the Laboratory of Nanoscale Biology in BIO  and the Laboratory for Condensed Matter in PSD have revealed the reaction between the nitrogen atoms of the amyloid-beta peptide and copper/zinc ions by using soft X-ray absorption spectroscopy.

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Roger Benoit

Protein distancing

Media Releases Biology Health Innovation

PSI researchers have developed a new method to attach proteins to the surface of virus-like particles.

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cryo-EM

Catching Alzheimer's Toxin

Single-particle cryo-electron microscopy of  a functional Aβ42 pore equivalent, created by fusing Aβ42 to the oligomerizing, soluble domain of the α-hemolysin  toxin, offers new insights into structure and function of proteins forming amyloid aggregates in Alzheimer’s disease.

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Teaser Tubulin

Cell cytoskeleton as target for new active agents

Media Releases Research Using Synchrotron Light Biology Health Innovation

Using a combination of computer simulations and laboratory experiments, PSI researchers have identified new binding sites for active agents on the vital protein tubulin.

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