Scientific Highlights

Production route of 44Sc

Promises of cyclotron-produced 44Sc as a diagnostic match for trivalent beta - emitters: In vitro and in vivo study of a 44Sc-DOTA-folate conjugate

Research Division Biology and Chemistry (BIO), Folate Receptor Targeting Group, Head Cristina Müller. In recent years, implementation of 68Ga-radiometalated peptides for PET imaging of cancer has attracted the attention of clinicians. Herein, we propose the use of 44Sc (half-life = 3.97 h, average β+ energy [Eβ+av] = 632 keV) as a valuable alternative to 68Ga (half-life = 68 min, Eβ+av = 830 keV) for imaging and dosimetry before 177Lu-based radionuclide therapy.

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